Martin C. Winer

This is what happens when Martin gets tired of sending mass emails.

Browsing Posts tagged cancer treatment

HealthCare

Some may say that the debate between Capitalism and Socialism has long been concluded with the fall of the Former Soviet Union. While it is true that large scale Communism will likely never be tried again, the debate continues in smaller forums. Michael Moore’s recent film ‘Sicko’ reignites this debate as it pertains to healthcare.

In so doing, the global pros and cons of either system need to be considered when applied to healthcare. The nutshell ‘con’ of Socialism is that it fails to motivate people and deliver supplies and resources efficiently. In turn, the nutshell ‘con’ of Capitalism is that it can be very cold and tunnel visioned, in that it is only profit seeking, which may go against the true desires of its citizens.

When we apply Capitalism or Socialism to healthcare we see the inherent strengths and weaknesses of either system manifest themselves. Specifically, we find Capitalism style healthcare too cold and non-inclusive. However, Socialized healthcare again has problems of motivation of healthcare providers and delivery of cutting edge technologies and services in a timely manner. We’ll work a few examples to flesh this out.

Suppose you are in your doctor’s office and, heaven forbid, you are given the most feared diagnosis in medicine: Cancer. You may or may not want to live in a country with Socialized medicine. This author lives in Canada which is far from the masterpiece of healthcare that Moore seems to paint in his film. I may remind Moore that another man’s grass is always greener and another man’s bill of health is always cleaner.

Canada has a long history of socialized institutions from gas, phone service, electric utilities, etc. to healthcare. But long gone are the halcyon days of government institutions. In recent years there has been a spate of privatization with private health clinics and tiered systems for healthcare already on the table. Having said all that, Canada still maintains a socialized healthcare system, at least for the moment.

Returning to our dreaded Cancer diagnosis, the word on the street in Canada is that our doctors are often not aggressive enough in treating Cancer. Many hugely expensive, yet promising, courses of treatments are avoided due to long wait times or simple unavailability. It is a common practice of Canadians to drive into Buffalo for example for a faster MRI. Having said all that, suppose you are low on funds and are recommended a course of chemotherapy. In this case, ignoring the wait times, you’d want to live in Canada where this is covered. Make no mistake about it, socialized medicine is something that I’m quite proud of as a Canadian, however, it is necessary to make sure we don’t exalt it as a panacea when in fact, it is not. In the final estimation it suffers from the same inherent problems of Socialism, lack of motivation and problems with resource delivery.

Turning our attention to Capitalism as it pertains to healthcare, we again will use Cancer as an example and this time we’ll examine the Pharmaceutical industry. Imagine for a second that I told you there was a new substance which, in mice, was able to shrink lung, breast and brain cancers. This substance was able to target Cancer cells specifically eliminating most, if not all, of the side effects of conventional cancer treatments. You’d think the pharmaceutical companies would be beating a path to the researcher’s door but they’re not. The reason? The compound the researcher works with is about as common as table salt. DCA (Dichloroacetic acid) is a common laboratory compound already available from any chemical supplier. Most importantly, it’s not patentable. As a result, drug companies have no way of recouping any money they pour into its research in human trials. As a result the researcher (Dr. Evangelos Michelakis out of the University of Alberta) is left to ‘pass the hat’ to try to collect the necessary funds to conduct the human trials. Here we see the tunnel vision of Capitalist style healthcare, overly focused on profit, while failing to accomplish the task it was assigned: providing health care.

Thus we see that neither Capitalism nor Socialism make the perfect pill for solving the problem of healthcare. What then do we turn to? We need only parse out ‘healthcare’ into its two parts, health and care. The key to the problem is in the caring. We can try for as long as we want, and as hard as we want to apply different methodologies, but in the end they will all fail if we try to remove ‘care’ from healthcare. In a socialized healthcare system, we still need doctors who care and are motivated and we need politicians to care enough to manage to keep up with the frenetic pace of healthcare developments. In a Capitalist style healthcare system, we need the system to care enough to occasionally ignore profits and look at the more global picture to avoid having the system tunnel visioned and not inclusive. In any case, the key metric for any healthcare system should be measured in units of caring.

Herbal Medicine

Canadian Bill C51 purportedly proposes sweeping changes to the herbal supplement and naturopathic/homeopathic remedies market.  The following excerpted from an anti Bill C51 website, although not independently confirmed, suggests that the bill would (amongst other things):

1) Fasttrack pharmaceutical drug approval and
2) Make over 70% percent of current herbal drugs illegal.

Now, this was taken from an opposing website so all claims must then be taken with a grain of all natural sea salt.  The Government claims that your access to Vitamin C and Echinacea is safe. 

“Under Bill C-51, Canadians will continue to have access to natural health products that are safe, effective and of high quality. The Bill will not limit access to natural health products nor does it call for a change in their regulatory status (from over-the-counter to prescription)” says Health Canada spokesperson Paul Duchesne.

Source :: http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20080509/C51_protests_080509/20080510?hub=TopStories

From that simple quote we are forced to ask the question, who and how will products be determined to be ‘safe, effective and of high quality’?  The contention seems to be over semantics and the definition of exactly which products will and will not be regulated.  Putting semantic issues aside, it looks as though the combatants are missing the more global issue and that is in addressing the manner in which the allopathic (mainstream) and alternative medicine operate.  The issue is probably more complex than first fathomed.  Both paradigms operate under different modi operandorum. 

Big pharma operates under the model of providing drugs and therapies with validated claims.  The drug’s claims and safety are established by clinical drug trials.  The benefits here should be obvious but the weaknesses of this system may not be.  The first failure of the big pharma model is that drug trials can be flawed either intentionally or just by simple lack of scope or experimental design.  Take for example the drug VIOXX which did pass clinical trials and FDA approval which was later associated with heart disease and voluntarily withdrawn by its manufacturer Merck. http://en.wikipedia.org/wiki/Rofecoxib#Withdrawal  The second failing of the big pharma model is even more subtle in that  only patentable therapies need apply.  Take for example the research Dr. Evangelos Michelak out of the university of Alberta who has come up with a cancer treatment using the chemical DCA. http://www.depmed.ualberta.ca/dca/  This treatment has been conclusively shown to remove or eradicate all manner of cancers in test animals.  It is a hugely promising therapy with suprisingly few side effects.  One would expect this drug to be in human trial by now.  However, since DCA is not patentable, (almost as common as table salt) the drug companies have no interest.  DCA will go to human trial nonetheless, but only after Dr. Evangelos Michelak is able to scrape together enough money from other philanthropic investors.

Now let’s examine the world of home or natural remedies.  You can pick up a bottle of an herbal remedy which can make all manner of claims.  These claims need not be validated and, indeed, the only validation you’ll receive is either from the smiling face of the salesperson at your natural foods store or the recommendation of a friend or naturopatic practitioner.  However, you probably won’t be able to rely on any study and you’ll have to adopt a ‘take it and try it’ approach.  The failings of this system are two fold.  First, hearkening back to the days of the snake oil salesmen, there is the potential for you to waste your time and money on ineffective remedies.  Second, in wasting your time on these remedies, you may delay seeking appropriate medical treatment for a potentially serious condition.  The first failure – the lack of study based findings — is compelling.  The natural health product industry needs to provide better support for their claims and adhere to some standard as for quality of composition. The second failure is not as compelling as people typically resort to natural health products only after the failure or reticence of allopathic medicine.

Looking at both paradigms, there is a measure which could marry their strengths and divorce ourselves of their weaknesses.  The summary of bill C51 reads as follows:

This enactment amends the Food and Drugs Act to modernize the regulatory system for foods and therapeutic products, to strengthen the oversight of the benefits and risks of therapeutic products throughout their life cycle, to support effective compliance and enforcement actions and to enable a greater transparency and openness of the regulatory system.

Source :: http://www2.parl.gc.ca/HousePublications/Publication.aspx?DocId=3398126&File=19

If this is indeed the goal of the Federal Government, then wouldn’t their time and efforts be better spent in implementing a system of subsidized and facilitated human trials?  A subsidized and facilitated human trials system would raise the bar for natural health food products to better support their claims.  Since the studies would be subsidized and facilitated we wouldn’t deny ourselves access to any reasonable therapy but as consumers, claims of product effectiveness and quality of composition could be properly backed by more than a friendly smile.  All therapies, herbal and pharmaceutical would be subject to the same level of testing.  This testing would be reasonably affordable for any given company.  This would satisfy the allopathic community’s demands for rigorous proof and testing while at the same time allow the allopathic community to consider previously unprofitable yet promising treatments such as DCA.

There is a petition circulating to stop bill C51.  http://www.thepetitionsite.com/1/StopC51  I would be willing to sign it if it could be proved it would make 70% of current natural health care products illegal.  Would I sign a petition to have the Federal Government fund and facilitate human trials of all health care products?  In a heartbeat.

Nanotechnology

There has been a spate of activity in the nanotech realm lately. Over the past few months I’ve tracked several new developments. Here they are in no particular order: spine, ram, solar cell, ca

Solar Film

1) Solar Power: The problem with solar technology is the high cost of the solar cells. The current level of technology in solar is in silicon wafer solar cells. They have low relative effeciency and a high relative cost. This makes them unfeasible as a replacement. Many companies, amont them Nanosolar of California, have developed a technology using nanoparticles which can absorb light more efficiently, but more importantly, more economically. Nanosolar is targetting a rate of $1/watt which would make solar power a viable alternative over nuclear or fossil fuels.

More amazing is the fact that the solar films can be mass produced and printed on to any building or surface. More details can be found here: http://www.economist.com/world/international/displaystory.cfm?story_id=10989479
http://www.nanosolar.com/

John Kanzius

2) Cancer Treatments:This story warms my heart on so many levels. John Kanzius was himself diagnosed with Leukemia. He underwent several bouts of painful chemotherapy. Not a physician but instead a retired radio and television engineer, he had a brainwave one night while sleeping. He came up with the idea of using radio waves to selectively target cancer cells while leaving the remaining healthy cells unscathed. Chemotherapy is based on the differential survivability of cancerous cells versus healthy cells. That is to say the chemicals used are toxic to both healthy and cancer cells, and the hope is that the cancer cells die out faster than the healthy ones: not a promising prospect.

Kanzius’ idea is remarkably different. He plans to send nanoparticles of gold into the tumor. He plans to use a targeting molecule attached to the gold nanoparticle to saturate the tumor with particles. Then he directs a highly concentrated radio beam towards the tumor. The gold heats up under influence of this beam and essentially the tumor is cooked.

Racetrack Memory

3) RAM-Memory: Hard discs have had a good run. They’ve given us a terabyte of storage at nominal cost and with reasonable access time. The technology of the future however will but much smaller, with no operating parts to wear out. The technology is called ‘Racetrack’ and is being developed in the Almaden Research Center in San Jose California. At the heart of the technology electron spin is used to code information. This information races along a nanowire at blazing speeds with very low power consumption. Future incarnations of this technology promise replace hard discs an allow for near instantaneous start up and uncompromising reliability.

Nano Fibres

4) Spinal Repair: We all recall fondly the heroic efforts of Christopher Reeve to bring about an awareness of spinal injury and the tragic effects it can have on the sufferers and their families. The problem with spinal injury, indeed most nerve injury, is that the injured site (referred to as a transection) forms a scar at either end of the cut bundle. Nerves do have the ability to regrow however, they lack the ability to bridge this scar. John Kessler, M.D., Davee Professor of Stem Cell Biology at Northwestern University’s Feinberg School of Medicine has come up with a gel of self assembling nanostructures which is injected at the injury site. Once inside, they go to work assembling a scaffolding which allows neural stem cells to bridge the gap. Mice with spinal injuries were injected with the compound and showed significant improvement including the ability to walk again.